ალიმენტური ტრაქტი და მეტაბოლიზმი
სისტემური გამოყენების ინფექციის საწინააღმდეგო
სისხლი და სისხლ-წარმომქმნელი ორგანოები
სამომავლოდ დაგეგმილი პროდუქტები
Ripronat (Injections / Capsules)
Capsules. Capsule of Ripronat contains 3-(2,2,2-trimethyihydrazinium) propionate
dihydrate 250 mg or 500 mg.
Ampoules. Ampoule of Ripronat contains 3-(2,2,2-trimethylhydrazinium) propionate
dihydrate 500 mg.
Ripronat is a structural analog of y-butirobetaine - carnitine precursor.
Carrying out the functions of y-butirobetaine, it accelerates nerve impulse
transmission in a human body. As the result all mental reactions are accelerated,
general metabolism is improved, a tonic effect is observed. There are memory
improvements, acceleration of performance of mental tasks, dexterity increasing,
and physical performance. It attenuates mental and exercise stress.
By inhibiting y-butirobetainehydroxylase the medicine decreases biosynthesis of
carnitine and transport of long chain fatty acids through cell membranes,
prevents accumulation of activated forms of unoxidized fatty acids - derivatives
of acylcarnitine and acylcoenzyme A, thus stopping their harmful action. In
conditions of ischemia it restores the balance between delivery and cells oxygen
demand. As the result of decrease of carnitine concentration y-butirobetaine (which
has vasodilating properties) is intensively synthesized. It delays tissue
necrosis, accelerates rehabilitation period in acute myocardial infarction. It
improves myocardial contractility and increases exercise tolerance in cardiac
The medicine can eliminates the functional disturbances of somatic and autonomic
nervous system in patients with chronic alcoholism in the period of abstinence.
It is well-absorbed following oral administration.
- complex therapy of IHD (angina, myocardial infarction), chronic cardiac
insufficiency and dyshormonal cardiomyopathy;
- complex therapy of acute and chronic cerebral circulation abnormalities (cerebral
strokes and cerebrovascular deficiency);
- decreased capacity for work, athletic overexertion (including sportsmen);
- for acceleration of rehabilitation in post surgery period;
- abstinence syndrome in chronic alcoholism (in combination with a specific
therapy of alcoholism).
- hypersensitization to the medicine;
- elevation of intracranial pressure (including, in disorders of venous outflow,
There are no sufficient data about safety and efficacy of Ripronat use in
children under 12 years old.
DOSAGE AND ADMINISTRATION:
Due to an excitory effect it is recommended to administer the medicine in the
first half of the day.
In cardiovascular diseases as a combined therapy the medicine is prescribed as
follows: 500-1000 mg/daily as a single dose or divided in two doses. The course
of treatment is 4- 6 weeks.
In cardialgia associated with dyshormonal cardiomyopathy Ripronat is prescribed
in dose 250 mg 2 times daily. The course of treatment is 12 days. In cerebral
circulation abnormalities in acute phase the medicine is prescribed
intravenously in 500 mg/daily during 10 days, then orally 500-1000 mg/daily. The
total therapy course is 4-6 weeks. In chronic cerebral circulation abnormalities
the medicine is taken in dose 500 mg/daily. The total therapy course 4-6 weeks.
The repeated courses are prescribed individually 2-3 times a year.
In mental and physical stress it is prescribed orally 250 mg 4 times daily. The
treatment is 10-14 days. Repeat the therapy in 2-3 weeks if necessary.
For sportsmen it is recommended to take 500-1000 mg 2 times daily before
duration of course in training period is 14-21 days; during competitions is
In chronic alcoholism the medicine is prescribed in 500 mg 4 times daily. The
treatment is 7-10 days.
10 capsules 250 mg in blister. 4 or 6 blisters with the leaflet in carton box.
15 capsules 500 mg in blister. 4 blisters with the leaflet in carton box. 10
ampoules with leaflet in carton box.