ალიმენტური ტრაქტი და მეტაბოლიზმი
სისტემური გამოყენების ინფექციის საწინააღმდეგო
სისხლი და სისხლ-წარმომქმნელი ორგანოები
სამომავლოდ დაგეგმილი პროდუქტები
Bronolac (Tablets / Syrup)
Tablets. Tablet contains ambroxol (as hydrochloride) 30 mg.
Syrup. Each 5 ml contains 15 mg ambroxol (as hydrochloride).
PHARMACODYNAMICS. Ambroxol (benzylamide group) refers to secretolytic and
secretomotor drugs. It has expressed expectoration effect. Mechanism of drug
action is due to the stimulation of serous adenocytes of bronchus mucous tunic,
the increase of mucin content and the change of ratio of serous and mucous
components of phlegm. Besides, hydrolyzing ferments are activated and the
lysosome release of Clare' s cells is strengthened that leads to the decrease of
phlegm viscosity. Ambroxol increases surfactant’s content in lungs due to
increase in the synthesis of the last by alveolar pneumocytes. It and also
decreases its disintegration. The drug increases a mucociliary phlegm transport.
The cough is neutralized slowly.
Ambroxol easily crosses placental barrier improving surfactant’s synthesis
during fetus intrauterine life, and also able to prevent the syndrome of
insufficient respiration in infants. The drug doesn’t cause an excessive
secretion formation, decreases spastic bronchial hyperreactivity, one of the
main developing factors of bronchial asthma during allergy.
PHARMACOKINETICS. After per oral application it is completely and fast absorbed
and easily penetrates in pulmonary tissue. Maximum blood plasma concentration is
reached in 2 hours after drug administration and is kept for 9 - 10 hours.
Ambroxol is eliminated through kidneys.
Diseases of respiratory tracts, requiring improvement in the elimination of
- acute and chronic bronchitis;
- chronic obstructive pulmonary diseases;
- bronchial asthma with impediment of phlegm discharge;
- bronchiectatic disease.
- hyper sensitivity to the drug;
- the first trimester of pregnancy.
From digestive system: rare - nausea, dry mouth, constipation; for longtime
administration in high dose - gastralgia, nausea, vomiting.
From respiratory system: rare - xerostomia, rhinorrhea;
Allergic reactions: skin eruption, urticaria, angioneurotic edema, in separate
cases - allergic contact dermatitis, anaphylactic shock.
Others: weakness, headache, dysuria, exanthema.
DOSAGE AND ADMINISTRATION:
Bronolac is administered orally after meal with sufficient amount of water.
The drug is prescribed to adults and children upwards 12 years in dosage 30 mg 2
- 3 times/day.
It is prescribed to children aged 5 - 12 years in dosage 15 mg 2 - 3 times/day.
It is prescribed to children aged 2 - 5 years in dosage 7.5 mg 3 times/day.
It is prescribed to children under 2 years in dosage 7.5 mg 2 times/day.
Duration of treatment is selected individually by the doctor and depends on
nature of disease.
It is not recommended to administer the drug more than 4 - 5 days without doctor
Co-administration with antitussive drugs leads to complication of phlegm
discharge against the background of cough decrease.
It increases the penetration in bronchial secretion of amoxicilin, cefuroxime,
erythromycin and doxycycline.
Ambroxol is compatible with drugs inhibiting birth activity.
10 tablets in blister.
2 blisters in carton box with enclosed leaflet.
Syrup. One vial in carton box with enclosed leaflet.